N-Acetyl Semax Amidate (20mg)

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N-acetyl Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment ACTH(4-7), modified with an N-terminal acetyl group and a C-terminal Pro-Gly-Pro extension. This structural adaptation enhances its stability against enzymatic degradation. N-acetyl Semax interacts with melanocortin receptors (MC₄ and MC₅), modulating pathways linked to cognitive function, stress response, and neuroprotection.

N-Acetyl Semax Amidate (20mg) Description

N-Acetyl Semax Amidate (20mg) is a stabilized synthetic peptide variant engineered through N-terminal acetylation and C-terminal amidation to resist enzymatic degradation and extend biological activity. This modification replaces the original peptide’s terminal carboxylic acid (-COOH) with an amide group (-NH₂), enhancing its stability.

Structurally defined as Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂, it demonstrates prolonged half-life (~30 minutes longer than standard Semax) and increased neuroprotective efficacy, modulating neurotransmitters like serotonin and dopamine and upregulating BDNF expression. Preclinical studies highlight its potential in cognitive enhancement, neuroregeneration, and therapeutic applications for stroke or neurodegenerative disorders.

N-Acetyl Semax Amidate (20mg) Peptide Information

Property Value
Peptide Sequence Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
Molecular Formula C37H51N9O10S
Molecular Weight 813.9 g/mol
CAS Number 80714-61-0
PubChem CID 9811102
Synonyms Semax, 80714-61-0, ACTH (4-7), Pro-Gly-Pro-, MEHFPGP, Met-Glu-His-Phe-Pro-Gly-Pro

Semax Peptide Structure

Semax.png

Source: PubChem

Product Usage:

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.

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