MetaShred

What Is MetaShred?

MetaShred is a combination of two mitochondrial modulators undergoing scientific investigation and currently used for research purposes only:

• BAM-15 (50mg per capsule): A mitochondrial uncoupler that enhances cellular respiration, increasing energy expenditure and thermogenesis without affecting ATP production efficiency.
• SLU-PP-332 (100mcg per capsule): A synthetic exercise mimetic that activates all three estrogen-related receptors (ERRα, ERRβ, ERRγ), stimulating mitochondrial biogenesis, fatty acid oxidation, and endurance-related gene expression.

Together, these compounds offer a unique research opportunity to study mitochondrial efficiency, metabolic regulation, and energy balance in preclinical models.

MetaShred Research Compounds and Mechanisms

1. BAM-15 – Mitochondrial Uncoupler

BAM-15 is a next-generation mitochondrial uncoupler that dissipates the proton gradient across the inner mitochondrial membrane, forcing mitochondria to increase oxygen consumption and burn more fuel without producing excess ATP.

• Increases metabolic rate and oxygen consumption by uncoupling oxidative phosphorylation.
• Enhances thermogenesis, promoting heat generation rather than energy storage.
• Reduces fat accumulation and improves insulin sensitivity in preclinical models.
• Does not disrupt plasma membrane potential, distinguishing it from classical uncouplers like FCCP and DNP.

Preclinical research has shown that BAM-15 reduces fat mass, improves mitochondrial flexibility, and enhances metabolic function in animal models of obesity and metabolic syndrome.

2. SLU-PP-332 – Pan-ERR Agonist and Exercise Mimetic

SLU-PP-332 is a potent exercise mimetic that activates all three estrogen-related receptors (ERRα, ERRβ, ERRγ), upregulating genes involved in fat oxidation, mitochondrial biogenesis, and muscle endurance.

• Increases mitochondrial respiration and oxidative capacity in skeletal muscle.
• Stimulates endurance-related genes, mimicking the effects of aerobic exercise.
• Promotes fatty acid oxidation and shifts metabolic preference away from glucose reliance.
• Reduces body fat and improves metabolic flexibility in research models of obesity.

SLU-PP-332-treated cellular and animal models show higher metabolic rates, increased oxygen consumption, and improved endurance performance—effects typically associated with prolonged aerobic training.

BAM-15 and SLU-PP-332 Synergy

MetaShred contains two complementary research compounds that work synergistically to enhance metabolic adaptation:

1. BAM-15 drives energy expenditure by uncoupling mitochondria, forcing an increase in caloric burn without directly stimulating physical activity.
2. SLU-PP-332 amplifies mitochondrial function and metabolic efficiency, increasing fat oxidation and mimicking the gene expression profile of endurance exercise.
3. Together, they create a unique research model for studying non-exercise-induced thermogenesis, metabolic disease interventions, and enhanced mitochondrial biogenesis.

This dual-action research approach makes MetaShred a valuable tool for investigating energy metabolism, mitochondrial dynamics, and novel metabolic therapies.

Molecular Structure and Data

BAM-15

• Chemical Name: N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
• CAS Number: 210302-17-3
• Molecular Formula: C₁₆H₁₀F₂N₆O
• Molecular Weight: 340.29 g/mol

SLU-PP-332

• Chemical Name: (E)-4-Hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide
• CAS Number: 303760-60-3
• Molecular Formula: C₁₈H₁₄N₂O₂
• Molecular Weight: 290.32 g/mol